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Her symptoms resolved, CK levels declined (Figure 1), and all abnormal laboratory values normalized within 3 days

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Dose escalation beyond the receptor saturation threshold increases systemic exposure, raises the risk of off-target effects (HGF receptors exist in liver, kidney, and vascular tissue), and wastes expensive research compounds

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Drasch G, der Mail S, Schlosser C, Roider G (2000) Content of non-mercury-associated selenium in human tissues